Onderstepoort Biological Products (OBP) : Clean Room Small-Scale Vaccine Production

Onderstepoort Biological Products (OBP) : Clean Room Small-Scale Vaccine Production

Controlling disease among the livestock herd and developing a healthy agricultural industry is an essential component of business at Onderstepoort Biological Products (OBP), where a variety of world-class vaccines for both indigenous and exotic diseases that attack livestock are produced. As a scientific as well as a  commercial enterprise, OBP has won international recognition and acclaim for its quality vaccines and ongoing research. To these ends, great care is taken in the preparation and production of vaccines.  

Given the variety and frequency of diseases present, there is in addition to the large scale production, a need to produce smaller volumes of special unique vaccines.  In accordance with the latest standards, an Esco Soft Wall Clean Room Laminar capsule was installed to protect the formulation process of the small-scale vaccine production operation.  This capsule was installed by Labotec, the local agents for Esco, and provides a clean dust-free working environment in accordance with ISO 9000.  

Esco offers a complete range of soft wall cleanrooms to meet various construction, dimensional and cleanliness class requirements.  OBP is using the soft capsule with dimensions of 4" x 8" x 7" (W X D X H) and an air volume of 2300m3/h.  The soft Isostat vinyl curtains isolate the cleanroom from the ambient environment to create a clean room area.  All exterior painted surfaces are also powder-coated with Esco Isocide, an antimicrobial inhibitor to minimize contamination that will not wash out or diminish by repeated cleaning. 

The cleanroom space is making it easier to maneuver the large flasks of up to 40kg that OBP is using for culture growth. Once the production process has been completed and the formulation moved into mobile vessels, release tests for sterility, safety and potency have to be done. Only then can the new vaccines be released to packaging for labelling and national distribution purposes. These uniquely designed vaccines are helping to control and build healthy herds for a healthy agricultural industry locally, as well as for parts in the rest of Africa; the Middle East; Mediterranean countries and South America.